A MODEL OF FUNCTIONAL EPISTASIS AND LINKAGE DISEQUILIBRIUM IN POPULATIONS WITH OVERLAPPING GENERATIONS
نویسندگان
چکیده
منابع مشابه
A model of functional epistasis and linkage disequilibrium in populations with overlapping generations.
A model of functional epistasis is proposed in which it is assumed that coupling and repulsion genotypes differ in metabolic efficiency and thus in development time and net fecundity. The implications of this model are investigated for iteroparous populations with fluctuating rates of increase. It is found that the fluctuations in rate of increase can lead to large fluctuations in gamete freque...
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Many insects and other arthropods harbor maternally inherited bacteria inducing "cytoplasmic incompatibility" (CI), reduced egg hatch when infected males mate with uninfected females. CI-causing infections produce a frequency-dependent reproductive advantage for infected females. However, many such infections impose fitness costs that lead to unstable equilibrium frequencies below which the inf...
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An inbreeding matrix is defined for populations with overlapping generations. In the short term it can be expressed in terms of a matrix specifying the passage of genes between the different age groups (and sexes) and a diagonal matrix whose elements depend on the number of individuals in each age group. Formulae for the inbreeding effective number are derived using matrix theory. A comparison ...
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Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their heterozygosity and altered their Malecot parameters, increas...
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ژورنال
عنوان ژورنال: Genetics
سال: 1977
ISSN: 1943-2631
DOI: 10.1093/genetics/86.3.679